Position located in Cambridge, MA
Responsibilities of the Contract Principal Scientist, DMPK:
- Design, execute, and interpret biotransformation studies to characterize drug metabolites.
- Conduct hands-on laboratory work, including sample preparation, LC-MS/MS, and high-resolution mass spectrometry (HRMS) for metabolite profiling.
- Oversee and manage outsourced studies with CROs, ensuring scientific quality and compliance with project timelines.
- Provide detailed interpretation of metabolite data to guide medicinal chemistry and safety assessment decisions.
- Develop, optimize, and validate innovative analytical methods to improve biotransformation workflows.
- Author and review high-quality scientific reports, regulatory submissions, and presentations.
- Collaborate effectively with cross-functional teams, including bioanalytical, toxicology and medicinal chemistry.
Requirements of the Contract Principal Scientist, DMPK:
- PhD in Chemistry, Biochemistry, Pharmaceutical Sciences, or a related discipline, with 3+ years of relevant industry experience.
- Strong expertise in drug metabolism, with hands-on experience using LC-MS/MS.
- Proficiency in GLP/GCP-compliant laboratory regulations, ICH guidelines and procedures.
- Familiarity with oligonucleotide biotransformation.
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