Position located in Cambridge, MA

Responsibilities of the Contract Principal Scientist, DMPK:

Design, execute, and interpret biotransformation studies to characterize drug metabolites.
Conduct hands-on laboratory work, including sample preparation, LC-MS/MS, and high-resolution mass spectrometry (HRMS) for metabolite profiling.
Oversee and manage outsourced studies with CROs, ensuring scientific quality and compliance with project timelines.
Provide detailed interpretation of metabolite data to guide medicinal chemistry and safety assessment decisions.
Develop, optimize, and validate innovative analytical methods to improve biotransformation workflows.
Author and review high-quality scientific reports, regulatory submissions, and presentations.
Collaborate effectively with cross-functional teams, including bioanalytical, toxicology and medicinal chemistry.

Requirements of the Contract Principal Scientist, DMPK:

PhD in Chemistry, Biochemistry, Pharmaceutical Sciences, or a related discipline, with 3+ years of relevant industry experience.
Strong expertise in drug metabolism, with hands-on experience using LC-MS/MS.
Proficiency in GLP/GCP-compliant laboratory regulations, ICH guidelines and procedures.
Familiarity with oligonucleotide biotransformation.

IND2

Commonwealth Sciences

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